CC12, a P450/epoxygenase inhibitor, acts in the rat rostral, ventromedial medulla to attenuate morphine antinociception
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چکیده
منابع مشابه
Administration of orexin receptor 1 antagonist into the rostral ventromedial medulla increased swim stress-induced antinociception in rat
Objective(s): Intracerebroventricular injection of orexin-A (hypocretin-1) antagonist has been shown to inhibit stress-induced analgesia. However the locations of central sites that may mediate these effects have not been totally demonstrated. This study was performed to investigate the role of rostral ventromedial medulla (RVM) orexin receptor 1 in stress-induced analgesia (SIA). Materials and...
متن کاملadministration of orexin receptor 1 antagonist into the rostral ventromedial medulla increased swim stress-induced antinociception in rat
objective(s): intracerebroventricular injection of orexin-a (hypocretin-1) antagonist has been shown to inhibit stress-induced analgesia. however the locations of central sites that may mediate these effects have not been totally demonstrated. this study was performed to investigate the role of rostral ventromedial medulla (rvm) orexin receptor 1 in stress-induced analgesia (sia). materials and...
متن کاملAdministration of orexin receptor 1 antagonist into the rostral ventromedial medulla increased swim stress-induced antinociception in rat
OBJECTIVES Intracerebroventricular injection of orexin-A (hypocretin-1) antagonist has been shown to inhibit stress-induced analgesia. However the locations of central sites that may mediate these effects have not been totally demonstrated. This study was performed to investigate the role of rostral ventromedial medulla (RVM) orexin receptor 1 in stress-induced analgesia (SIA). MATERIALS AND ...
متن کاملPhysiological basis for inhibition of morphine and improgan antinociception by CC12, a P450 epoxygenase inhibitor.
Many analgesic drugs, including μ-opioids, cannabinoids, and the novel nonopioid analgesic improgan, produce antinociception by actions in the rostral ventromedial medulla (RVM). There they activate pain-inhibiting neurons, termed "OFF-cells," defined by a nociceptive reflex-related pause in activity. Based on recent functional evidence that neuronal P450 epoxygenases are important for the cent...
متن کاملorexin-a modulates firing of rat rostral ventromedial medulla neurons: an in vitro study
the rostral ventromedial medulla (rvm) acts a key role in the descending inhibitory pain modulation. neuropeptide orexin-a (orxa) is confined to thousands of neurons in the lateral hypothalamus (lh). while rvm gets the orexinergic projections, the orexin receptors are also expressed in this structure. the aim of this study was to specify the cellular effects of orxa on rvm neurons in vitro by u...
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ژورنال
عنوان ژورنال: Brain Research
سال: 2013
ISSN: 0006-8993
DOI: 10.1016/j.brainres.2012.12.030